1. Hold Windows key + R.
   
2. Copy and paste  or type the following command in the Open box, and then press Enter
   

          %temp%

Windows Explorer opens in the Temporary folder > Press Ctrl+A to select all the contents and Delete.

Note: If there are any files in use, skip them.

Method 2:

Try Working in Excel safe and check if it helps. To know how to start Excel in Safe mode, follow the steps below.

Hold the windows key + Letter ‘R’ from the keyboard to launch the Run command > Copy and paste the following command line in the open box and click Ok.

Excel /safe

If Excel safe works as expected, disable the add-ins as suggested below: 

1. Click on File menu.
   
2. Click Options.
   
3. Click Add-ins.
   
4. Click on Go button besides Manage: Com-Add-in.
   
5. Check if there are add-ins listed, clear the checkbox to disable them.
   
6. Close the Excel and restart it.  
   

If the spreadsheets are not created on this machine (downloaded or transferred from another machine), try the following steps and check if it helps:

1.  Right click on the excel file.
   
2.  Select Properties.
   
3. Remain on General tab.
   
4. Scroll to the bottom of the General tab and select "Unblock" to unblock the file.
   

Repair the Office suite as suggested in the following link and check if it helps:

http://office.microsoft.com/en-us/excel-help/repair-office-programs-HA010357402.aspx